HuagongsheHuagongshe Chemistry Print Report · For research reference only
3-Hydroxybenzaldehyde → HCID 86590217, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 3-Hydroxybenzaldehyde | HCID 101 | — |
| Reactant | Ethyl cyanoacetate | HCID 7764 | — |
| Reactant | Ethyl Thioglycolate | HCID 12185 | — |
| Reactant | Phosphorus oxychloride | HCID 24813 | — |
| Reactant | 2-Methyl-2-thiopseudourea sulfate | HCID 75270 | — |
| Reactant | HCID 22597575 | HCID 22597575 | — |
| Reactant | HCID 22597658 | HCID 22597658 | — |
| Solvent | Dichloromethane ethylacetate | HCID 21226138 | — |
| Product | HCID 86590217 | HCID 86590217 | — |
Reaction Steps
Cyclization of S-methylisothiourea sulfate (139 mg), 3-{2-[5-methyl-2-phenylimidazol-4-yl]ethoxy}benzaldehyde (496 mg, synthesized from 3-hydroxybenzaldehyde (489 mg) and 4-chloroethyl-5-methyl-2-phenylimidazole (1.03 g) via the procedure described in example 79a) and ethyl cyanoacetate (112 μl), treatment of the product with POCl3 and subsequent reaction with ethyl 2-mercaptoacetate were performed according to the methods described in example 1. The pure title compound was obtained after chromathography on silicagel in dichloromethane/ethyl acetate=10010 (v/v)→70(30 (v/v) as eluent.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06569863B1 |
| Source dataset | uspto-grants-2003_05 |
| ORD ID | ord-af844466ee394f08a47a228c05971625 |
| Source note | uspto-grants-2003_05 |