Methyl 2,5-dibromopentanoate → Methyl 5-bromo-2-(5-ethoxycarbonyl-2-nitrophenoxy)valerate

Participants

Reaction Steps

By a process similar to that of Reference Example 5, ethyl 3-hydroxy-4-nitrobenzoate was allowed to react with methyl 2,5-dibromovalerate to give methyl 5-bromo-2-(5-ethoxycarbonyl-2-nitrophenoxy)valerate as an oily product (yield: 80.2%). This product was subjected to catalytic reduction to obtain ethyl 2-(3-bromopropyl)-3,4-dihydro-3-oxo-2H-1,4-benzoxazine-7-carboxylate, m.p. 118°-119° C. The yield was 90.7%.

Provenance & Evidence