6-Nitro-1,3-benzodioxol-5-ol → Methyl 5-bromo-2-(4,5-methylenedioxy-2-nitrophenoxy)valerate

Participants

Reaction Steps

In a manner similar to that of Reference Example 5, 4,5-methylenedioxy-2-nitrophenol was allowed to react with methyl 2,5-dibromovalerate to give methyl 5-bromo-2-(4,5-methylenedioxy-2-nitrophenoxy)valerate, which was then allowed to react, in a manner similar to that of Reference Example 8, with 1-(4-fluorophenyl)piperazine to obtain methyl 5-[4-(4-fluorophenyl)-1-piperazinyl]-2-(4,5-methylenedioxy-2-nitrophenoxy)valerate as crystals, m.p. 98°-99° C. The overall yield was 15.6%.

Provenance & Evidence