HuagongsheHuagongshe Chemistry Print Report · For research reference only
Acetone → (-)-N-n-propyl-2-(3-bromo-2-hydroxy-6-methoxybenzamidomethyl)pyrrolidine hydrochloride
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Acetone | HCID 180 | — |
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | (-)-N-n-propyl-2-(3-bromo-2,6-dimethoxybenzamidomethyl)pyrrolidine | HCID 13493825 | — |
| Solvent | Ethanol | HCID 702 | — |
| Product | (-)-N-n-propyl-2-(3-bromo-2-hydroxy-6-methoxybenzamidomethyl)pyrrolidine hydrochloride | HCID 21282682 | 48% |
Reaction Steps
The title compound was prepared from (-)-N-n-propyl-2-(3-bromo-2,6-dimethoxybenzamidomethyl)pyrrolidine by dealkylation in the same manner as described in Example 2. Yield 48%. M.p. (HCl) 140°-141° C. (acetone). [α]D25 =-78° C. (c=0.80, EtOH) base.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04789683 |
| Source dataset | uspto-grants-1988_12 |
| ORD ID | ord-e76b91104b514909b27c0f27ca878d6c |
| Source note | uspto-grants-1988_12 |