HuagongsheHuagongshe Chemistry Print Report · For research reference only
Acetone → (-)-N-n-propyl-2-(3-bromo-6-hydroxy-2-methoxybenzamidomethyl)pyrrolidine hydrochloride
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Acetone | HCID 180 | — |
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | (-)-N-n-propyl-2-(3-bromo-2,6-dimethoxybenzamidomethyl)pyrrolidine | HCID 13493825 | — |
| Solvent | Methanol | HCID 887 | — |
| Product | (-)-N-n-propyl-2-(3-bromo-6-hydroxy-2-methoxybenzamidomethyl)pyrrolidine hydrochloride | HCID 21282684 | 55% |
Reaction Steps
The title compound was prepared from (-)-N-n-propyl-2-(3-bromo-2,6-dimethoxybenzamidomethyl)pyrrolidine by dealkylation in the same manner as described in Example 2. Yield 55%. M.p. (HCl) 137°-138° C. (acetone). [α]D25 =-68° C. (c=0.12; MeOH).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04789683 |
| Source dataset | uspto-grants-1988_12 |
| ORD ID | ord-f550d560464c4728b7f75712a9516be3 |
| Source note | uspto-grants-1988_12 |