Piperidine → 1-(o-chlorobenzyl)-1H-1,2,3-triazole-4-carboxylic acid piperidide

Participants

Reaction Steps

In a manner analogous to that described in Example 14, starting from 11.8 g (50 mmol) of 1-(o-chlorobenzyl)-1H-1,2,3-triazole-4-carboxylic acid, converting this into the acid chloride and treating the latter with piperidine (50 mmol), there is obtained 1-(o-chlorobenzyl)-1H-1,2,3-triazole-4-carboxylic acid piperidide having a melting point of 141°-142° (from ethanol) and, by treating the acid chloride with dimethylamine (50 mmol), there is obtained 1-(o-chlorobenzyl)-1H-1,2,3-triazole-4-carboxylic acid N,N-dimethylamide having a melting point of 120°-121° (from ethanol).

Provenance & Evidence