2-Butynoic acid → HCID 21282641, compound

HRID 414095Notes

Reaction equation

HRID 414095 reaction equation
[Cl:1][C:2]1[C:7]([CH2:8][N:9]=[N+:10]=[N-:11])=[C:6]([F:12])[CH:5]=[CH:4][CH:3]=1.[C:13]([C:16]([OH:18])=[O:17])#[C:14]C>C1(C)C=CC=CC=1>[Cl:1][C:2]1[C:7]([CH2:8][N:9]2[CH:14]=[C:13]([C:16]([OH:18])=[O:17])[N:11]=[N:10]2)=[C:6]([F:12])[CH:5]=[CH:4][CH:3]=1

Participants

4

Reactant 2

HCID 685352-Butynoic acidHCID 21282616106308-56-9

Product 1

HCID 21282641HCID 21282641, compound

Reagents, catalysts & solvents 1

HCID 1140TolueneSolvent

Procedure

27.5 g (0.15 mole) of 6-chloro-2-fluorobenzyl azide and 10.5 g (0.15 mole) of propinecarboxylic acid in 300 ml of toluene are heated for 3 hours to 90° C. After cooling, the crystals are filtered with suction and recrystallised from acetonitrile to give 1-(6-chloro-2-fluorobenzyl)-1H-1,2,3-triazole-4-carboxylic acid with a melting point of 182° C. (dec.).

Workup

  1. temperatureAfter cooling
  2. filtrationthe crystals are filtered with suction
  3. customrecrystallised from acetonitrile

Sources & evidence

ORD record
ord-4082f467ae4d45f496d8a2db01834ebd
Source dataset
uspto-grants-1988_12
Patent number
US04789680

Reaction notes

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