Formamide → N-formyl-L-aspartic acid

HRID 414132Notes

Reaction equation

HRID 414132 reaction equation
[NH2:1][C@H:2]([C:7]([OH:9])=[O:8])[CH2:3][C:4]([OH:6])=[O:5].[CH:10](N)=[O:11]>>[CH:10]([NH:1][C@H:2]([C:7]([OH:9])=[O:8])[CH2:3][C:4]([OH:6])=[O:5])=[O:11]

Participants

3

Reactant 2

HCID 713FormamideHCID 5960L-Aspartic Acid2×

Product 1

HCID 88052N-formyl-L-aspartic acid

Procedure

Under a nitrogen atmosphere, a slurry of 2.7 gm (20 mmol) L-aspartic acid in 4.0 ml (100 mmol) formamide was heated at 95°-100° C. for 2 hours. Examination of the resulting homogeneous mixture by proton NMR showed that the L-aspartic acid had been completely converted to its N-formyl derivative.

Sources & evidence

ORD record
ord-560ca5dbb0af4314bb824fd49f08e609
Source dataset
uspto-grants-1988_12
Patent number
US04789757

Reaction notes

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