HuagongsheHuagongshe Chemistry Print Report · For research reference only
Ammonia → 5-Methoxy-2-(4-methyl-2-pyridylthiomethyl)benzimidazole
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Ammonia | HCID 222 | — |
| Reactant | 4-Methoxybenzene-1,2-diamine hydrochloride | HCID 12252900 | — |
| Reactant | Ethyl 2-(4-methyl-2-pyridylthio)acetate | HCID 21281961 | — |
| Solvent | Hydrochloric Acid | HCID 313 | — |
| Product | 5-Methoxy-2-(4-methyl-2-pyridylthiomethyl)benzimidazole | HCID 21281953 | — |
Reaction Steps
10.6 g of ethyl 2-(4-methyl-2-pyridylthio)acetate (0.05 mole) and 8.8 g of 4-methoxy-1,2-phenylenediamine hydrochloride (0.05 mole) in 400 ml of 6N hydrochloric acid are heated under reflux for 2 days. The mixture is allowed to cool and is neutralized with ammonia solution. It is extracted with ethyl acetate (3×100 ml), and the extract is dried (Na2SO4), filtered and concentrated to a volume of 75 ml. From this solution, 8.4 g (59%) of 5-methoxy-2-(4-methyl-2-pyridylthiomethyl)benzimidazole, melting point 138°-140° C., crystallize. The data for the identification of the product appear in Tables 1 and 2.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04791114 |
| Source dataset | uspto-grants-1988_12 |
| ORD ID | ord-e9dbed3d682d449db8c119668b2829df |
| Source note | uspto-grants-1988_12 |