反应详情

To a suspension of 25 g 2-methyl-lysergic acid in 500 ml CH3OH are added 253 ml 3.5N HCl/CH3OH. The reaction mixture is then stirred at room temperature for 15 hours, then diluted with 500 ml CH3OH and stirred 2 days. The mixture is evaporated and partitioned between ethyl acetate and 5% K2CO3 solution. After drying and evaporating the heading compound is obtained as crystals, which are then rubbed with ether/hexane (1:1), m.p. 154° (sintering 150°).

1. stirringstirred 2 days
2. customThe mixture is evaporated
3. custompartitioned between ethyl acetate and 5% K2CO3 solution
4. customAfter drying
5. customevaporating the heading compound
6. customis obtained as crystals, which