HuagongsheHuagongshe Chemistry Print Report · For research reference only
Triethylamine → HCID 70406371, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Triethylamine | HCID 8471 | — |
| Reactant | Pivaloyl chloride | HCID 62493 | — |
| Reactant | 9,10-Didehydro-6-methylergolin-8alpha-amine | HCID 10657638 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | HCID 70406371 | HCID 70406371 | — |
Reaction Steps
A suspension of 5.5 g 8α-amino-6-methyl-9,10-didehydro-ergoline in 200 ml CH2Cl2 is cooled to 0° and treated with 6.44 ml triethylamine followed by dropwise addition of 2.97 ml pivaloyl chloride. The mixture is stirred for 2 hours at room temperature and washed with water. The organic layer is dried (Na2SO4) and evaporated. The residue is chromatographed on 200 g silica gel using 98:2 CH2Cl2 /CH3OH and then crystallized from ether to yield 6-methyl-8α-pivaloylamino-9,10-didehydro-ergoline, m.p. 158°-159°.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04791115 |
| Source dataset | uspto-grants-1988_12 |
| ORD ID | ord-0a5afd457cc642a581ed07cdd00190af |
| Source note | uspto-grants-1988_12 |