2-Methyl-2-propylpropane-1,3-diol → HCID 14349832, compound

HRID 414211Notes

Reaction equation

HRID 414211 reaction equation
[Cl:1][C:2]1[N:3]=[N:4][C:5]([Cl:8])=[CH:6][CH:7]=1.[CH3:9][C:10]([CH2:15][CH2:16][CH3:17])(CO)[CH2:11][OH:12]>CCCCCCC>[Cl:1][C:2]1[N:3]=[N:4][C:5]([Cl:8])=[CH:6][C:7]=1[C:10]([CH2:11][OH:12])([CH3:9])[CH2:15][CH2:16][CH3:17]

Participants

4

Reactant 2

HCID 662202-Methyl-2-propylpropane-1,3-diolHCID 673313,6-Dichloropyridazine

Product 1

HCID 14349832HCID 14349832, compound

Reagents, catalysts & solvents 1

HCID 8900HeptaneSolvent

Procedure

Twenty g. of 3,6-dichloropyridazine was alkylated with 44.4 g. of 2-methyl-2-propyl-1,3-propanediol, following the process of Preparation 3 above. In this case the chromatography was run with 3:1 heptane:ethyl acetate as the eluant, and the residue from evaporation of the combined product-containing fractions was recrystallized from diethyl ether/heptane to obtain 0.43 g. of the desired intermediate product, m.p. 99°-100°.

Workup

  1. customthe process of Preparation 3 above
  2. customethyl acetate as the eluant, and the residue from evaporation of the
  3. additioncombined product-containing fractions
  4. customwas recrystallized from diethyl ether/heptane
  5. customto obtain 0.43 g

Sources & evidence

ORD record
ord-2bbf3cbfe461416495285967310871aa
Source dataset
uspto-grants-1988_12
Patent number
US04791110

Reaction notes

Loading…