Lawesson's reagent → HCID 14424280, compound

HRID 414226Notes

Reaction equation

HRID 414226 reaction equation
[CH3:1][C:2]1[S:6][C:5]([C:7](=O)[CH2:8][NH:9][C:10](=O)[C:11]2[CH:16]=[C:15]([C:17]([F:20])([F:19])[F:18])[CH:14]=[C:13]([C:21]([F:24])([F:23])[F:22])[CH:12]=2)=[CH:4][CH:3]=1.COC1C=CC(P2(SP(C3C=CC(OC)=CC=3)(=S)S2)=[S:36])=CC=1>C1(C)C=CC=CC=1>[CH3:1][C:2]1[S:6][C:5]([C:7]2[S:36][C:10]([C:11]3[CH:16]=[C:15]([C:17]([F:20])([F:19])[F:18])[CH:14]=[C:13]([C:21]([F:24])([F:23])[F:22])[CH:12]=3)=[N:9][CH:8]=2)=[CH:4][CH:3]=1

Participants

4

Reactant 2

HCID 87949Lawesson's reagentHCID 21282002HCID 21282002, compound

Product 1

HCID 14424280HCID 14424280, compoundYield 50.8%

Reagents, catalysts & solvents 1

HCID 1140TolueneSolvent2×

Procedure

In a manner similar to Example 1, the reaction of N-[2-(5-methylthienyl)-2-oxoethyl]-3,5-bis(trifluoromethyl)benzamide (4.0 g, 0.01 mole) in toluene (100 ml) with a suspension of Lawesson's Reagent (2.0 g, 0.005 mole) in toluene (100 ml) yielded 1.0 g of 5-(5-methylthien-2-yl)-2-[3,5-bis(trifluoromethyl)phenyl]thiazole as a solid, m.p. 119.5°-121° C.

Sources & evidence

ORD record
ord-e23988f767a24d0b8bfbcf954da4a6c7
Source dataset
uspto-grants-1988_12
Patent number
US04791124

Reaction notes

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