HCID 21281919, compound → HCID 70417539, compound

Participants

Reaction Steps

A mixture of 9.7 parts of 1-[2-(1-methylethoxy)ethyl]-3-[4-[4-[4-(phenylmethoxy)phenyl]-1-piperazinyl]phenyl]-2-imidazolidinone and 250 parts of acetic acid was hydrogenated at normal pressure and at 50° C. with 2 parts of palladium-on-charcoal catalyst 10%. After the calculated amount of hydrogen was taken up, the catalyst was filtered off and the filtrate was evaporated. The residue was dissolved in a mixture of methanol and water and the whole was neutralised with a sodium hydrogen carbonate solution. The precipitated product was filtered off and crystallized from 4-methyl-2-pentanone. The product was filtered off and dried at 100° C., yielding 6.3 parts (76.8%) of 1-[4-[4-(4-hydroxyphenyl)-1-piperazinyl]phenyl]-3-[2-(1-methylethoxy)ethyl]-2-imidazolidinone hemihydrate; mp. 178.3° C. (intermediate 28).

Provenance & Evidence