Imidazole → HCID 21282297, compound

Participants

Reaction Steps

The title compound was prepared as described in Example 13, starting with 4-(4-chlorobutoxyphenyl)-2-phenylthiazole (7.8 g, 18 mmol) and using imidazole (3.8 g, 55 mmol) in place of dibutylamine to produce 3.6 g (53% yield) of the free base of the title compound which was converted to the HCl salt, mp 178°-180° C. IR(KBr): 3500, 2720, 1615 cm-1, MS: 376(MH+). 1H NMR (CD3OD): δ9.00 (s, 1H), 8.03-6.96 (m, 12H), 4.38 (t, J=6.0 Hz, 2H), 4.09 (t, J=6.0 Hz, 2H), 2.22-1.79 (m, 4H).

Provenance & Evidence