Imidazole → HCID 54416035, compound

Participants

Reaction Steps

The title compound was prepared as described in Example 22 using 4-[3,5-dichloro-4-(chloropropoxy)phenyl]-2-phenylthiazole (4.2 g, 11 mmol) and imidazole (2.2 g, 33 mmol) in place of dibutylamine to give 1.9 g (40% yield) of the free base of the title compound which was converted to the HCl salt, mp 204°-207° C. IR(KBr): 3400, 2540 cm-1, MS: 430(MH+). 1H NMR (CD3OD): δ9.08 (brs, 1H), 8.03-7.48 (m, 10H), 4.65 (t, J=5.0 Hz, 2H), 4.12 (t, J=4.5 Hz, 2H), 2.50 (m, 2H).

Provenance & Evidence