反应详情

In 40 ml of ethanol, 6.9 g of 6-imidazo[1,2-a]pyridinecarbaldehyde was stirred under reflux for 14 hours, together with 10.6 g of nitroethane and 30 drops of n-butyl amine. Then, a small quantity of ethyl amine was added thereto and the mixture was stirred under reflux for further 18 hours. After insoluble matter was removed by filtration upon heating, 50 ml of ethanol and 150 ml of ether were further added to remove insoluble matter by filtration. The solvent was removed by distillation under reduced pressure and the residue was recrystallized twice from ethanol to obtain 1.14 g of 6-(2-nitro-1-propenyl)imidazo[1,2-a]pyridine.

1. temperatureunder reflux for further 18 hours
2. customAfter insoluble matter was removed by filtration
3. temperatureupon heating
4. addition50 ml of ethanol and 150 ml of ether were further added
5. customto remove insoluble matter
6. filtrationby filtration
7. customThe solvent was removed by distillation under reduced pressure
8. customthe residue was recrystallized twice from ethanol