HuagongsheHuagongshe Chemistry Print Report · For research reference only
Propionyl chloride → Propionyl Oxazolidinone
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Propionyl chloride | HCID 62324 | — |
| Reactant | 2-Oxazolidinone | HCID 73949 | — |
| Reactant | Butyllithium | HCID 178418339 | — |
| Solvent | Hexane | HCID 8058 | — |
| Product | Propionyl Oxazolidinone | HCID 641554 | — |
Reaction Steps
Following the cyclization reaction, the formed oxazolidinone is N-acylated to form the nucleophilic precursor of the molecule. The oxazolidinone is reacted with butyllithium in hexane, to form the conjugate base and then reacted with an acyl halide such as propionyl chloride at -71° C., for 0.5-1 hour to yield the N-propionyloxazolidinone.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04791207 |
| Source dataset | uspto-grants-1988_12 |
| ORD ID | ord-1c2084addbcf4a2fa795a1edf0ddad25 |
| Source note | uspto-grants-1988_12 |