Sulfuric Acid → 2,3-Dichloro-4,5-difluorobenzamide

HRID 414365Notes

Reaction equation

HRID 414365 reaction equation
[Cl:1][C:2]1[C:9]([Cl:10])=[C:8]([F:11])[C:7]([F:12])=[CH:6][C:3]=1[C:4]#[N:5].S(=O)(=O)(O)[OH:14]>>[Cl:1][C:2]1[C:9]([Cl:10])=[C:8]([F:11])[C:7]([F:12])=[CH:6][C:3]=1[C:4]([NH2:5])=[O:14]

Participants

3

Reactant 2

HCID 1118Sulfuric AcidHCID 140963672,3-Dichloro-4,5-difluorobenzonitrile

Product 1

HCID 140963682,3-Dichloro-4,5-difluorobenzamide

Procedure

A solution of 2,3-dichloro-4,5-difluorobenzonitrile (1.0 g) in concentrated sulfuric acid (2.5 ml) was stirred at 90° to 100° C. for 30 minutes and then cooled. The residue was poured into ice water and the resulting precipitate was collected by filtration and recrystallized from benzene to give the title compound (0.51 g) as colorless needles, mp 153°-155° C.

Workup

  1. temperaturecooled
  2. filtrationthe resulting precipitate was collected by filtration
  3. customrecrystallized from benzene

Sources & evidence

ORD record
ord-daf80a6adebf416a8087b9e7fc30cb5e
Source dataset
uspto-grants-1988_12
Patent number
US04791225

Reaction notes

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