Sulfuric Acid → 2,3-Dichloro-4,5-difluorobenzoic acid

HRID 414366Notes

Reaction equation

HRID 414366 reaction equation
[Cl:1][C:2]1[C:10]([Cl:11])=[C:9]([F:12])[C:8]([F:13])=[CH:7][C:3]=1[C:4](N)=[O:5].S(=O)(=O)(O)[OH:15]>>[Cl:1][C:2]1[C:10]([Cl:11])=[C:9]([F:12])[C:8]([F:13])=[CH:7][C:3]=1[C:4]([OH:15])=[O:5]

Participants

3

Reactant 2

HCID 1118Sulfuric AcidHCID 140963682,3-Dichloro-4,5-difluorobenzamide

Product 1

HCID 139380362,3-Dichloro-4,5-difluorobenzoic acid

Procedure

A mixture of 2,3-dichloro-4,5-difluorobenzamide (0.5 g) and 18N-sulfuric acid (2.5 ml) was stirred at 125° to 135° C. for 9 hours, and then poured into ice water. After standing overnight, the resulting precipitate was collected by filtration and recrystallized from hexane-benzene to give the title compound (0.3 g) as colorless prisms.

Workup

  1. waitAfter standing overnight
  2. filtrationthe resulting precipitate was collected by filtration
  3. customrecrystallized from hexane-benzene

Sources & evidence

ORD record
ord-bca41dfd152b4789a29d2a3ac59a5c4f
Source dataset
uspto-grants-1988_12
Patent number
US04791225

Reaction notes

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