N-(4,5-Difluoro-2-nitrophenyl)acetamide → 4,5-Difluoro-2-nitroaniline

Participants

Reaction Steps

A solution of N-(4,5-difluoro-2-nitrophenyl)acetamide (70 g) in concentrated hydrochloric acid (110 ml) and ethanol (440 ml) was refluxed for 2 hours. The reaction mixture was poured into ice water (1.5 liter) and the resulting precipitate was collected by filtration and washed with chilled water sufficiently to give the title compound (53.2 g) as yellow prisms, mp 109°-109.5° C.

Provenance & Evidence