Potassium Carbonate → HCID 21280642, compound

Participants

Reaction Conditions

Reaction Steps

Into a dry 250 ml three-necked flask kept under dry nitrogen and fitted with a reflux condenser and internal thermometer was added 2-methoxymethyl-3,4,4-trimethyl-1,3-oxazolidinium iodide (7.13 grams, 25 mmole), powdered potassium carbonate (8.97 grams, 65 mmole) and 125 ml dry benzene. The heterogeneous mixture was heated at 70° C. for 90 minutes before addition of 5-nitroso-6-quinolinol (5.44 grams, 25 mmole). The resulting reaction mixture was heated at 70° C. for 17 hours, cooled and filtered through Celite® diatomaceous earth powder. The solvent was removed in vacuo from the filtrate, and the resulting residue purified by flash chromatography to yield 0.33 grams of 2'-methoxy-3,4,4-trimethylspiro [oxazolidine-2,3'-[3H] pyrido [3,2-f] [1,4] benzoxazine].

Provenance & Evidence