Felbinac → HCID 21280934, compound

HRID 414466Notes

Reaction equation

HRID 414466 reaction equation
[C:1]1([C:11]2[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=2)[CH:6]=[CH:5][C:4]([CH2:7][C:8]([OH:10])=O)=[CH:3][CH:2]=1.CO[C:19](=[O:26])[C@H:20]([CH2:22][CH2:23][CH2:24][CH3:25])[NH2:21].[CH3:27][CH:28]1[CH2:33][NH:32][CH2:31][CH:30]([CH3:34])[NH:29]1>>[CH3:27][CH:28]1[NH:29][CH:30]([CH3:34])[CH2:31][N:32]([C:19]([CH:20]([NH:21][C:8](=[O:10])[CH2:7][C:4]2[CH:3]=[CH:2][C:1]([C:11]3[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=3)=[CH:6][CH:5]=2)[CH2:22][CH2:23][CH2:24][CH3:25])=[O:26])[CH2:33]1

Participants

4

Reactant 3

HCID 3332FelbinacHCID 660562,6-DimethylpiperazineHCID 7018840HCID 7018840, compound

Product 1

HCID 21280934HCID 21280934, compound

Procedure

Following the procedure of Example 3, and using 4-biphenylacetic acid, norleucine methyl ester and 2,6-dimethylpiperazine, there is obtained the title compound in 375 mg yield.

Sources & evidence

ORD record
ord-9c8cfc9489a44bed93b64da399321ffb
Source dataset
uspto-grants-1988_12
Patent number
US04792555

Reaction notes

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