反应详情

To 9.44 g (36.0 mmol) of said ethyl 5-(2,4-dimethoxyphenyl)-2,4-pentadienoate was added 80 ml of methanol to give a solution. To thesolution was then added a solution of 14.40 g (360 mmol) of sodium hydroxide dissolved in 20 ml of water, and the mixture was stirred at room temperature for 2 hours. The resulting mixture was concentrated under reduced pressure followed by addition of water and a hydrochloric acid solution to adjust the pH to 1 and extraction with chloroform. The organic layer was washed with water and a saturated aqueous sodium chloride solution and then dried over anhydrous magnesium sulfate. Concentration under reduced pressure gave 7.70 g (32.9 mmol) of 5-(2,4-dimethoxyphenyl)-2,4-pentadienoic acid.

1. customto give a solution
2. concentrationThe resulting mixture was concentrated under reduced pressure
3. additionfollowed by addition of water
4. extractionto 1 and extraction with chloroform
5. washThe organic layer was washed with water
6. dry with materiala saturated aqueous sodium chloride solution and then dried over anhydrous magnesium sulfate
7. concentrationConcentration under reduced pressure