Triethylamine → 1-Benzhydryl-4-(5-(2,3,4-trimethoxyphenyl)-2,4-pentadienoyl)piperazine

Participants

Reaction Conditions

Reaction Steps

To 7.3 g (27.6 mmol) of 5-(2,3,4-trimethoxyphenyl)-2,4-pentadienoic acid were added 300 ml of dry dichloromethane and 3.85 ml (27.6 mmol) of triethylamine, and the mixture was stirred at 0° C. To the resulting mixture was added 2,64 ml (27,6 mmol) of ethylcarbonyl chloride followed by stirring for 1 hour. To the mixture was added 8.36 g (33 mmol) of benzhydrylpiperazine in 50 ml of dry dichloromethane. Temperature of the mixture was raised to room temperature followed by stirring for additional 16 hours. After addition of water, the mixture was extracted with dichloromethane. The organic layer was washed successively with aqueous 1N-hydrochloric acid solution, a saturated aqueous sodium chloride solution and a saturated aqueous sodium hydrogen carbonate solution and a saturated aqueous sodium chloride solution. The organic layer was dried over anhydrous magnesium sulfate and concentrated under reduced pressure. There was obtained a residue, which was subjected to column chromatography on silica gel to give 10.0 g (20.1 mmol) of 1-benzhydryl-4-(5-(2,3,4-trimethoxyphenyl)-2,4-pentadienoyl)piperazine from eluates of ethyl acetate-hexane (1:1).

Provenance & Evidence