HuagongsheHuagongshe Chemistry Print Report · For research reference only
Carbonic acid-guanidine (1:1) → Aditeren
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Carbonic acid-guanidine (1:1) | HCID 286947 | — |
| Reactant | Sodium | HCID 5360545 | — |
| Reactant | 4'-(3-Anilino-2-cyano-allyl)-2',6'-dimethoxy-formanilide | HCID 86740092 | — |
| Solvent | Water | HCID 962 | — |
| Product | Aditeren | HCID 176875 | — |
Reaction Steps
A solution of 1.84 g. of sodium in 200 ml. of absolute alcohol was treated with 14.4 g. guanidine carbonate and 8.9 g. of 4'-(3-anilino-2-cyano-allyl)-2',6'-dimethoxy-formanilide and refluxed for 20 hours. Then, 200 ml. of water were added and the alcohol was removed under vacuum. After standing at room temperature for 2 hours, the crystals formed were removed by filtration with suction, washed with water and recrystallized from methanol, whereby there was obtained 2,4-diamino-5-(4-amino-3,5-dimethoxy-benzyl)-pyrimidine having a melting point of 215°-216° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04792557 |
| Source dataset | uspto-grants-1988_12 |
| ORD ID | ord-023acfce3a31477593b23bb8fe5cc290 |
| Source note | uspto-grants-1988_12 |