Sodium borohydride → 6-[1-Hydroxy-2-(imidazol-1-yl)ethyl]-3,4-dihydrocarbostyril

HRID 414557Notes

Reaction equation

HRID 414557 reaction equation
[N:1]1([CH2:6][C:7]([C:9]2[CH:10]=[C:11]3[C:16](=[CH:17][CH:18]=2)[NH:15][C:14](=[O:19])[CH2:13][CH2:12]3)=[O:8])[CH:5]=[CH:4][N:3]=[CH:2]1.[BH4-].[Na+]>CO>[OH:8][CH:7]([C:9]1[CH:10]=[C:11]2[C:16](=[CH:17][CH:18]=1)[NH:15][C:14](=[O:19])[CH2:13][CH2:12]2)[CH2:6][N:1]1[CH:5]=[CH:4][N:3]=[CH:2]1

Participants

4

Reactant 2

HCID 4311764Sodium borohydrideHCID 14207262HCID 14207262, compound

Product 1

HCID 143732926-[1-Hydroxy-2-(imidazol-1-yl)ethyl]-3,4-dihydrocarbostyril

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

A solution of 3.0 g of 6-(imidazol-1-ylacetyl)-3,4-dihydrocarbostyril (the preparation of which is given in Example 3) in 120 ml of methanol was reacted with 1.2 g of sodium borohydride in the same manner as shown in Preparation 2, and the product similarly isolated to give 6-[1-hydroxy-2-(imidazol-1-yl)ethyl]-3,4-dihydrocarbostyril, m.p. 182°-184°

Workup

  1. customas shown in Preparation 2
  2. customthe product similarly isolated

Sources & evidence

ORD record
ord-2e13988fc0894e948f18828a378db452
Source dataset
uspto-grants-1988_12
Patent number
US04792561

Reaction notes

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