6-[3-(Imidazol-1-yl)prop-1-yn-1-yl]-3,4-dihydrocarbostyril → 6-[3-(Imidazol-1-yl)propyl]-3,4-dihydrocarbostyril

HRID 414564Notes

Reaction equation

HRID 414564 reaction equation
[N:1]1([CH2:6][C:7]#[C:8][C:9]2[CH:10]=[C:11]3[C:16](=[CH:17][CH:18]=2)[NH:15][C:14](=[O:19])[CH2:13][CH2:12]3)[CH:5]=[CH:4][N:3]=[CH:2]1>[Pd]>[N:1]1([CH2:6][CH2:7][CH2:8][C:9]2[CH:10]=[C:11]3[C:16](=[CH:17][CH:18]=2)[NH:15][C:14](=[O:19])[CH2:13][CH2:12]3)[CH:5]=[CH:4][N:3]=[CH:2]1

Participants

3

Reactant 1

HCID 143732826-[3-(Imidazol-1-yl)prop-1-yn-1-yl]-3,4-dihydrocarbostyril

Product 1

HCID 143732856-[3-(Imidazol-1-yl)propyl]-3,4-dihydrocarbostyril

Reagents, catalysts & solvents 1

HCID 23938PalladiumCatalyst

Procedure

A solution of 502 mg of 6-[3-(imidazol-1-yl)prop-1-yn-1-yl]-3,4-dihydrocarbostyril was stirred under hydrogen in the presence of 200 mg of a 10% palladium on charcoal catalyst as shown in Example 8, and the product was isolated in a similar fashion, giving 6-[3-(imidazol-1-yl)propyl]-3,4-dihydrocarbostyril, m.p. 139°-141° C.

Workup

  1. customthe product was isolated in a similar fashion

Sources & evidence

ORD record
ord-445b9f47e7634c39b684c09d762ddda7
Source dataset
uspto-grants-1988_12
Patent number
US04792561

Reaction notes

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