HuagongsheHuagongshe Chemistry Print Report · For research reference only
5-Bromoisoindoline → (2,4-Bis-benzyloxy-5-isopropenyl-phenyl)-(5-bromo-1,3-dihydro-isoindol-2-yl)-methanone
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 5-Bromoisoindoline | HCID 14795871 | — |
| Reactant | 2,4-Bis(benzyloxy)-5-isopropenylbenzoic acid | HCID 49864016 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | (2,4-Bis-benzyloxy-5-isopropenyl-phenyl)-(5-bromo-1,3-dihydro-isoindol-2-yl)-methanone | HCID 46915776 | — |
Reaction Steps
Coupling of 2,4-bis-benzyloxy-5-isopropenyl-benzoic acid (5.0 g, 13.4 mmol) (Preparation B9) and 5-bromo-2,3-dihydro-1H-isoindole (Preparation C20) was completed according to method A4, using CH2Cl2 as the reaction solvent to give the title compound (8.34 g) as a beige solid.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08530469B2 |
| Source dataset | uspto-grants-2013_09 |
| ORD ID | ord-cef9f9e57d31466583e2722ebf376fbb |
| Source note | uspto-grants-2013_09 |