P-Cresol → 4-Methyl-2-(methylthio)phenol

HRID 414668노트

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HRID 414668 반응식
[CH:1]1[C:6]([OH:7])=[CH:5][CH:4]=[C:3]([CH3:8])[CH:2]=1.[CH3:9][S:10]C1C=CC(O)=CC=1>>[CH3:9][S:10][C:1]1[CH:2]=[C:3]([CH3:8])[CH:4]=[CH:5][C:6]=1[OH:7]

참가 물질

3

반응물 2

HCID 2879P-CresolHCID 140864-(Methylthio)phenol

생성물 1

HCID 131993354-Methyl-2-(methylthio)phenol수율 58.4%

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온도
176 °C

실험 절차

p-Cresol (1.2 g, 0.01 mole), para-(methylthio)phenol (3.0 g, 0.02 mole), and H ELZ-20 from Example 27 (1.0 g) were combined and heated at 176° C. for 14 hours. The mixture was cooled to room temperature and filtered. The catalyst was washed several times with ether. The filtrate and ether washings were combined, and volatiles were removed on a rotary flash evaporator. GC analysis indicated the presence of 2-methylthio-4-methylphenol (0.9 g, 56% yield).

후처리

  1. temperatureThe mixture was cooled to room temperature
  2. filtrationfiltered
  3. washThe catalyst was washed several times with ether
  4. customvolatiles were removed on a rotary flash evaporator

출처 및 근거

ORD 기록
ord-207dd439457540148d10e8b7ac909510
출처 데이터셋
uspto-grants-1988_12
특허 번호
US04792633

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