N-Methylol-alpha-chloroacetamide → 4-Methyl-6-alpha-chloroacetylaminomethyl-7-hydroxy-1-indanone

Participants

Reaction Steps

9.3 Grams of 4-methyl-7-hydroxy-1-indanone and 30 g of N-hydroxymethyl-α-chloroacetamide were dissolved by adding 280 ml of concentrated sulfuric acid under a cooling condition. After the mixture was allowed to stand overnight, the mixture was poured into ice-water. The crystals formed in the mixture were collected by filtration and were recrystallized from ethanol to obtain 49 g of 4-methyl-6-α-chloroacetylaminomethyl-7-hydroxy-1-indanone.

Provenance & Evidence