反应详情

Into a solution of 36 g of 4-methyl-7-hydroxy-1-indanone and 17.6 g of potassium hydroxide in 650 ml of methanol was added 25 ml of allyl bromide, and the mixture was refluxed by heating for 6 hours. The insoluble matters in the reaction mixture were removed by filtration, then the solvent was removed by evaporation. The residue obtained was extracted with chloroform-water, and the chloroform layer was collected by separation, then the solvent was removed by evaporation. The residue thus obtained was washed with ether and purified by means of a column chromatography to obtain 32 g of 4-methyl-7-allyloxy-1-indanone.

1. temperaturethe mixture was refluxed
2. temperatureby heating for 6 hours
3. customThe insoluble matters in the reaction mixture were removed by filtration
4. customthe solvent was removed by evaporation
5. customThe residue obtained
6. extractionwas extracted with chloroform-water
7. customthe chloroform layer was collected by separation
8. customthe solvent was removed by evaporation
9. customThe residue thus obtained
10. washwas washed with ether
11. custompurified by means of a column chromatography