反应详情

Into a solution of 10 g of 4-methyl-7-hydroxy-1-indanone and 5.3 g of potassium hydroxide in 200 ml of methanol was added 8.2 ml of crotyl bromide, and the mixture was refluxed by heating for 4 hours. The insoluble matters in the reaction mixture were removed by filtration, then the solvent was removed by evaporation. The residue obtained was extracted with chloroform-water, and the chloroform layer was washed with a diluted sodium hydroxide aqueous solution, then washed with water, dried with anhydrous magnesium sulfate, and the solvent was removed by evaporation. The residue obtained was purified by means of a silica gel column chromatography (eluent: n-hexane: dichloromethane=1:1) to obtain 8.72 g of 4-methyl-7-crotyloxy-1-indanone.

1. temperaturethe mixture was refluxed
2. temperatureby heating for 4 hours
3. customThe insoluble matters in the reaction mixture were removed by filtration
4. customthe solvent was removed by evaporation
5. customThe residue obtained
6. extractionwas extracted with chloroform-water
7. washthe chloroform layer was washed with a diluted sodium hydroxide aqueous solution
8. washwashed with water
9. dry with materialdried with anhydrous magnesium sulfate
10. customthe solvent was removed by evaporation
11. customThe residue obtained
12. customwas purified by means of a silica gel column chromatography (eluent: n-hexane: dichloromethane=1:1)