反应详情

Into a solution of 15 g of 4-methyl-7-hydroxy-1-indanone and 7.95 g of potassium hydroxide in 200 ml of methanol was added 13.55 ml of methallyl chloride, and the mixture was refluxed by heating for 11 hours. The insoluble matters in the reaction mixture were removed by filtration, then the solvent was removed by evaporation. The residue obtained was purified by means of a silica gel column chromatography (eluent: n-hexane: dichloromethane=1:1) to obtain 9 g of 4-methyl-7-methallyloxy-1-indanone.

1. temperaturethe mixture was refluxed
2. temperatureby heating for 11 hours
3. customThe insoluble matters in the reaction mixture were removed by filtration
4. customthe solvent was removed by evaporation
5. customThe residue obtained
6. customwas purified by means of a silica gel column chromatography (eluent: n-hexane: dichloromethane=1:1)