反应详情

Into a solution of 2 g of 7-hydroxy-4-methyl-1-indanone in 10 ml of dichloroethane was added 2.27 g of 1-piperidine sulfonyl chloride. Then 10 g of anhydrous aluminum chloride was gradually added to the mixture and stirred, and the reaction mixture was refluxed by heating for 8 hours. The reaction mixture was extracted with 200 ml of chloroform, washed with water, then the chloroform was removed by evaporation under a reduced pressure. The residue was purified by means of a silica gel column chromatography (eluent: chloroform), and recrystallized from ethanol to obtain 1.24 g of 7-hydroxy-4-methyl-6-(1-piperidinesulfonyl)-1-indanone.

1. temperaturethe reaction mixture was refluxed
2. temperatureby heating for 8 hours
3. extractionThe reaction mixture was extracted with 200 ml of chloroform
4. washwashed with water
5. customthe chloroform was removed by evaporation under a reduced pressure
6. customThe residue was purified by means of a silica gel column chromatography (eluent: chloroform)
7. customrecrystallized from ethanol