反应详情

5 Grams of 1-amino-7-hydroxy-4-methylindane was dissolved in 30 ml of acetic acid, then an acetic acid solution containing 1.73 ml of bromine was added and stirred at a room temperature for 1 hour. The crystals precipitated were collected by filtration, and were recrystallized from isopropanol to obtain 2 g of 1-amino-6-bromo-7-hydroxy-4-methylindane hydrobromide in the form of yellow needle-like crystals. Melting point: 178°-190° C. (decomp.) The structure was determined by means of NMR.

1. additionwas added
2. customThe crystals precipitated
3. filtrationwere collected by filtration
4. customwere recrystallized from isopropanol