Bromine → 1-Amino-6-bromo-7-hydroxy-4-methylindane hydrobromide

HRID 414689Notes

Reaction equation

HRID 414689 reaction equation
[NH2:1][CH:2]1[C:10]2[C:5](=[C:6]([CH3:12])[CH:7]=[CH:8][C:9]=2[OH:11])[CH2:4][CH2:3]1.[Br:13]Br>C(O)(=O)C>[BrH:13].[NH2:1][CH:2]1[C:10]2[C:5](=[C:6]([CH3:12])[CH:7]=[C:8]([Br:13])[C:9]=2[OH:11])[CH2:4][CH2:3]1

Participants

4

Reactant 2

HCID 24408BromineHCID 136041691-Amino-7-hydroxy-4-methylindane

Product 1

HCID 136041901-Amino-6-bromo-7-hydroxy-4-methylindane hydrobromide

Reagents, catalysts & solvents 1

HCID 176Acetic AcidSolvent2×

Procedure

5 Grams of 1-amino-7-hydroxy-4-methylindane was dissolved in 30 ml of acetic acid, then an acetic acid solution containing 1.73 ml of bromine was added and stirred at a room temperature for 1 hour. The crystals precipitated were collected by filtration, and were recrystallized from isopropanol to obtain 2 g of 1-amino-6-bromo-7-hydroxy-4-methylindane hydrobromide in the form of yellow needle-like crystals. Melting point: 178°-190° C. (decomp.) The structure was determined by means of NMR.

Workup

  1. additionwas added
  2. customThe crystals precipitated
  3. filtrationwere collected by filtration
  4. customwere recrystallized from isopropanol

Sources & evidence

ORD record
ord-0b6a17e11e144518ac97c08fd3eb1a4c
Source dataset
uspto-grants-1988_12
Patent number
US04792628

Reaction notes

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