反应详情

5.75 Grams of 1-amino-7-hydroxy-4-methylindane hydrochloride was suspended in 40 ml of acetic acid, then 3.27 ml of acetic anhydride and a solution consisting of 2.59 ml of concentrated nitric acid and 10 ml of acetic acid were added thereto, and the whole mixture was stirred at a room temperature for 6 hours. The solvent was removed by evaporation, the residue was washed with acetone and recrystallized from ethanol to obtain 2 g of 1-amino-7-hydroxy-4-methyl-6-nitroindane hydrochloride in the form of yellow needle-like crystals. Melting point: 200°-230° C. (decomp.).

1. additionwere added
2. customThe solvent was removed by evaporation
3. washthe residue was washed with acetone
4. customrecrystallized from ethanol