Dimethylamine → HCID 70381902, compound

HRID 414708Notes

Reaction equation

HRID 414708 reaction equation
[CH3:1][NH:2][CH3:3].[Cl:4][CH2:5][C:6]([C:8]1[N:9]([CH:13]([C:20]2[CH:25]=[CH:24][CH:23]=[CH:22][C:21]=2[F:26])[C:14]2[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=2)[CH:10]=[CH:11][CH:12]=1)=[O:7]>CO>[ClH:4].[CH3:1][N:2]([CH2:5][C:6]([C:8]1[N:9]([CH:13]([C:20]2[CH:25]=[CH:24][CH:23]=[CH:22][C:21]=2[F:26])[C:14]2[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=2)[CH:10]=[CH:11][CH:12]=1)=[O:7])[CH3:3]

Participants

4

Reactant 2

HCID 674DimethylamineHCID 9996568HCID 9996568, compound

Product 1

HCID 70381902HCID 70381902, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Conditions

Temperature
85 °C

Procedure

To a solution of methanol saturated with dimethylamine was added 1-[(2-fluorophenyl)phenylmethyl]pyrrol-2-yl chloromethyl ketone (20.39 g in 500 ml of MeOH). This was heated at an oil bath temperature of 85° C. and stirred for 2 hours.

Sources & evidence

ORD record
ord-caa3f462bb944804905b770462d54cae
Source dataset
uspto-grants-1988_12
Patent number
US04794110

Reaction notes

Loading…