Ethyl 6-bromo-2,2-dimethylhexanoate → Ethyl 7-[p-[3-(1-imidazolyl)propoxy]phenoxy]-2,2-dimethylheptanoate

HRID 414727Notes

Reaction equation

HRID 414727 reaction equation
[N:1]1([CH2:6][CH2:7][CH2:8][O:9][C:10]2[CH:15]=[CH:14][C:13]([OH:16])=[CH:12][CH:11]=2)[CH:5]=[CH:4][N:3]=[CH:2]1.Br[CH2:18][CH2:19][CH2:20][CH2:21][CH2:22][C:23]([CH3:30])([CH3:29])[C:24]([O:26][CH2:27][CH3:28])=[O:25].N1(CCCCCOC2C=CC(O)=CC=2)C=CN=C1.BrCCCCC(C)(C)C(OCC)=O>>[N:1]1([CH2:6][CH2:7][CH2:8][O:9][C:10]2[CH:11]=[CH:12][C:13]([O:16][CH2:18][CH2:19][CH2:20][CH2:21][CH2:22][C:23]([CH3:29])([CH3:30])[C:24]([O:26][CH2:27][CH3:28])=[O:25])=[CH:14][CH:15]=2)[CH:5]=[CH:4][N:3]=[CH:2]1

Participants

5

Reactant 4

HCID 10444833Ethyl 6-bromo-2,2-dimethylhexanoateHCID 11265571Ethyl 7-bromo-2,2-dimethylheptanoateHCID 132191404-{[5-(1H-Imidazol-1-yl)pentyl]oxy}phenolHCID 23042691p-[3-(1-Imidazolyl)propoxy]phenol

Product 1

HCID 13575701Ethyl 7-[p-[3-(1-imidazolyl)propoxy]phenoxy]-2,2-dimethylheptanoate

Procedure

p-[3-(1-Imidazolyl)propoxy]phenol and ethyl 7-bromo-2,2-dimethylheptanoate were used as starting compounds in place of p-[5-(1-imidazolyl)pentyloxy]phenol and ethyl 6-bromo-2,2-dimethylhexanoate, respectively, in EXAMPLE 30. The starting compounds were heated and treated in a manner similar to EXAMPLE 30 to give the desired product, ethyl 7-[p-[3-(1-imidazolyl)propoxy]phenoxy]-2,2-dimethylheptanoate, as an oily substance.

Workup

  1. temperatureThe starting compounds were heated
  2. additiontreated in a manner similar to EXAMPLE 30

Sources & evidence

ORD record
ord-a058a5e97cda4c599b185bd912ebb906
Source dataset
uspto-grants-1988_12
Patent number
US04794113

Reaction notes

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