Sodium Hydroxide → 5-(1H-Tetrazol-1-yl)pentanoic acid

HRID 414738Notes

Reaction equation

HRID 414738 reaction equation
C([O:3][C:4](=[O:14])[CH2:5][CH2:6][CH2:7][CH2:8][N:9]1[CH:13]=[N:12][N:11]=[N:10]1)C.[OH-].[Na+]>CO>[N:9]1([CH2:8][CH2:7][CH2:6][CH2:5][C:4]([OH:14])=[O:3])[CH:13]=[N:12][N:11]=[N:10]1

Participants

4

Reactant 2

HCID 14798Sodium HydroxideHCID 53833799(5-Tetrazol-1-yl)-valeric acid ethyl ester

Product 1

HCID 212802905-(1H-Tetrazol-1-yl)pentanoic acid

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

2.12 g of (5-tetrazol-1-yl)-valeric acid ethyl ester are dissolved in 5 ml of methanol, and 4.28 ml of a methanolic NaOH solution (3N) are added. After stirring for 2.5 hours at room temperature, the solvent is distilled off and the residue is taken up in water. After washing with ethyl acetate, the aqueous phase is acidified (pH 3) and extracted twice with ethyl acetate. After drying and concentration by evaporation, the pure title compound is obtained.

Workup

  1. distillationthe solvent is distilled off
  2. washAfter washing with ethyl acetate
  3. extractionextracted twice with ethyl acetate
  4. customAfter drying
  5. concentrationconcentration
  6. customby evaporation

Sources & evidence

ORD record
ord-414e0b081d944a87a3826097904e4a0d
Source dataset
uspto-grants-1988_12
Patent number
US04794109

Reaction notes

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