反应详情

2.12 g of (5-tetrazol-1-yl)-valeric acid ethyl ester are dissolved in 5 ml of methanol, and 4.28 ml of a methanolic NaOH solution (3N) are added. After stirring for 2.5 hours at room temperature, the solvent is distilled off and the residue is taken up in water. After washing with ethyl acetate, the aqueous phase is acidified (pH 3) and extracted twice with ethyl acetate. After drying and concentration by evaporation, the pure title compound is obtained.

1. distillationthe solvent is distilled off
2. washAfter washing with ethyl acetate
3. extractionextracted twice with ethyl acetate
4. customAfter drying
5. concentrationconcentration
6. customby evaporation