HuagongsheHuagongshe Chemistry Print Report · For research reference only
1-Tetrazolylacetic acid → (1H-Tetrazol-1-yl)acetyl chloride
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 1-Tetrazolylacetic acid | HCID 543207 | — |
| Reactant | 1-Chloro-N,N-2-trimethylpropenylamine | HCID 640792 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | (1H-Tetrazol-1-yl)acetyl chloride | HCID 13232854 | — |
Reaction Steps
1.58 g of 2-(tetrazol-1-yl)-acetic acid are suspended in 27 ml of absolute methylene chloride, and 1.9 ml of 1-chloro-1-dimethylaminoisobutene (CDIB) are added. After stirring for 30 minutes at room temperature, a further 0.5 ml of CDIB is added and stirring is continued for a further 90 minutes. This solution of the acid chloride [IR (methylene chloride): 3.20, 5.57 μm] is further reacted directly.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04794109 |
| Source dataset | uspto-grants-1988_12 |
| ORD ID | ord-bc76faeb95b649a3839f1a594e1e3f60 |
| Source note | uspto-grants-1988_12 |