Chloroacetyl chloride → HCID 131715799, compound

HRID 414747Notes

Reaction equation

HRID 414747 reaction equation
[CH2:1]([O:4][C:5](=[O:41])[C:6]([N:26]1[C@H:29]([SH:30])[C@@H:28]([C:31]([CH3:39])([CH3:38])[O:32][SiH2:33][C:34]([CH3:37])([CH3:36])[CH3:35])[C:27]1=[O:40])=[P:7]([C:20]1[CH:25]=[CH:24][CH:23]=[CH:22][CH:21]=1)([C:14]1[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=1)[C:8]1[CH:13]=[CH:12][CH:11]=[CH:10][CH:9]=1)[CH:2]=[CH2:3].[Cl:42][CH2:43][C:44](Cl)=[O:45]>[Ag]>[CH2:1]([O:4][C:5](=[O:41])[C:6]([N:26]1[C@H:29]([S:30][C:44](=[O:45])[CH2:43][Cl:42])[C@@H:28]([C:31]([CH3:39])([CH3:38])[O:32][SiH2:33][C:34]([CH3:35])([CH3:37])[CH3:36])[C:27]1=[O:40])=[P:7]([C:14]1[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=1)([C:20]1[CH:21]=[CH:22][CH:23]=[CH:24][CH:25]=1)[C:8]1[CH:9]=[CH:10][CH:11]=[CH:12][CH:13]=1)[CH:2]=[CH2:3]

Participants

4

Reactant 2

HCID 6577Chloroacetyl chlorideHCID 131715800HCID 131715800, compound

Product 1

HCID 131715799HCID 131715799, compound

Reagents, catalysts & solvents 1

HCID 23954SilverCatalyst

Procedure

In a manner analogous to that described in Example 7, 30 g of the silver salt of 2-[(3S,4R)-3-(tert.-butyl-dimethyl-silyloxymethyl)-4-mercapto-2-oxoazetidin-1-yl]-2-triphenylphosphoranylideneacetic acid allyl ester are reacted with 5.04 ml of chloroacetyl chloride to form the title compound.

Sources & evidence

ORD record
ord-9d3415c54c98461fbe37d38115c44edf
Source dataset
uspto-grants-1988_12
Patent number
US04794109

Reaction notes

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