Sodium Hydroxide → 5-(1H-Tetrazol-1-yl)pentanoic acid

HRID 414749Notes

Reaction equation

HRID 414749 reaction equation
C([O:3][C:4](=[O:14])[CH2:5][CH2:6][CH2:7][CH2:8][N:9]1[CH:13]=[N:12][N:11]=[N:10]1)C.[OH-].[Na+]>CO>[N:9]1([CH2:8][CH2:7][CH2:6][CH2:5][C:4]([OH:14])=[O:3])[CH:13]=[N:12][N:11]=[N:10]1

Participants

4

Reactant 2

HCID 14798Sodium HydroxideHCID 53833799(5-Tetrazol-1-yl)-valeric acid ethyl ester

Product 1

HCID 212802905-(1H-Tetrazol-1-yl)pentanoic acid

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

2.12 g of 5-(tetrazol-1-yl)-valeric acid ethyl ester are dissolved in 5 ml of methanol, and 4.28 ml of a methanolic NaOH solution (3N) are added thereto. After stirring for 2.5 hours at room temperature, the solvent is distilled off and the residue is taken up in water. After washing with ethyl acetate, the aqueous phase is acidified (pH 3) and extracted twice with ethyl acetate. After drying and concentrating by evaporation, the pure title compound is obtained.

Workup

  1. distillationthe solvent is distilled off
  2. washAfter washing with ethyl acetate
  3. extractionextracted twice with ethyl acetate
  4. customAfter drying
  5. concentrationconcentrating by evaporation

Sources & evidence

ORD record
ord-bc54d1b92dcf44adb42d55f7c87236b9
Source dataset
uspto-grants-1988_12
Patent number
US04794109

Reaction notes

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