Pyridine → HCID 70407612, compound

Participants

Reaction Conditions

Reaction Steps

1.512 g of dl-trans-2-hexadecyloxymethyltetrahydropyran-3-yl 2-bromoethyl phosphate (prepared as described in the first half of Example 1) was dissolved in 20 ml of pyridine, and the resulting solution was heated, with stirring, at 80° C. for 20 hours. The mixture was then cooled and the pyridine was removed by distillation under reduced pressure. The residue was subjected to column chromatography through 45 g of silica gel. The fraction eluted with a 60:35:5 by volume mixture of methylene chloride, methanol and water gave 1.422 g of the title compound as a white powder, melting at 123°-129° C.

Provenance & Evidence