Lithium tri-s-butylborohydride → HCID 22841016, compound

Participants

Reaction Steps

Jones oxidation was carried out by the same procedure as described in Preparation 3, but using 2.22 g of dl-trans-2-benzyloxymethyl-3-hydroxytetrahydropyran (prepared as described in Preparation 6). The crude substance, 2.08 g, obtained in this way was dissolved in 10 ml of tetrahydrofuran, and 12 ml of a 1M tetrahydrofuran solution containing L-selectride were added dropwise to this solution at 0°-5° C. Using the same procedure and purification as described in Preparation 4, 1.135 g of the title compound was obtained as a colorless liquid, boiling at 130°-140° C. (bath temperature)/1 mmHg (133 Pa).

Provenance & Evidence