反应详情

2.77 g of ethyl (Z)-2-[(2-pyrrolidon-3-yl)oxyimino]-3-oxo-4-chloro-n-butyrate and 1.2 g of acetylthiourea are added to 20 ml of ethanol, and 2.0 g of N,N-dimethylaniline are added thereto. The mixture is stirred at 20° to 30° C. for 4 hours. Then, the mixture is concentrated under reduced pressure to drynss. The residue is dissolved in chloroform, and the solution is washed with water and an aqueous sodium bicarbonate solution, successively. The chloroform solution is dried and concentrated under reduced pressure to remove solvent. The residue is crystallized with isopropanol, and the crystals are collected by filtration. 1.7 g of ethyl (Z)-2-(2-acetamidothiazol-4-yl)-2-[(2-pyrrolidon-3-yl)oxyimino]acetate are obtained.

1. additionare added
2. concentrationThen, the mixture is concentrated under reduced pressure
3. dissolutionThe residue is dissolved in chloroform
4. washthe solution is washed with water
5. dry with materialThe chloroform solution is dried
6. concentrationconcentrated under reduced pressure
7. customto remove solvent
8. customThe residue is crystallized with isopropanol
9. filtrationthe crystals are collected by filtration