反应详情

49 g of (Z)-2-(2-tritylaminothiazol-4-yl)-2-[(2-pyrrolidon-3-yl)oxyimino]acetic acid are suspended in a solution of one liter of methanol containing 40 ml of water, and the suspension is refluxed for 2 hours with heating. After cooling, crystalline precipitates are collected by filtration, and the crystals are washed with ethyl acetate. The crystals are recrystallized from a mixture of 500 ml of methanol and 50 ml of water, and dried at 70° C. under reduced pressure. 15.7 g of (Z)-2-(2-aminothiazol-4-yl)-2-[(2-pyrrolidon-3-yl)oxyimino]acetic acid are obtained as colorless prisms. The physico-chemical properties of this product are identical with those of the product obtained in Example 2-(4).

1. temperaturethe suspension is refluxed for 2 hours
2. temperaturewith heating
3. temperatureAfter cooling
4. customcrystalline precipitates
5. filtrationare collected by filtration
6. washthe crystals are washed with ethyl acetate
7. customThe crystals are recrystallized from a mixture of 500 ml of methanol and 50 ml of water
8. customdried at 70° C. under reduced pressure