1-{3-[(Quinolin-2-yl)methoxy]phenyl}hexan-1-ol → HCID 21280496, compound

HRID 414844Notes

Reaction equation

HRID 414844 reaction equation
[OH:1][CH:2]([C:8]1[CH:9]=[C:10]([CH:23]=[CH:24][CH:25]=1)[O:11][CH2:12][C:13]1[CH:22]=[CH:21][C:20]2[C:15](=[CH:16][CH:17]=[CH:18][CH:19]=2)[N:14]=1)[CH2:3][CH2:4][CH2:5][CH2:6][CH3:7].[C:26](OC(=O)C)(=[O:28])[CH3:27]>N1C=CC=CC=1>[C:26]([O:1][CH:2]([C:8]1[CH:9]=[C:10]([CH:23]=[CH:24][CH:25]=1)[O:11][CH2:12][C:13]1[CH:22]=[CH:21][C:20]2[C:15](=[CH:16][CH:17]=[CH:18][CH:19]=2)[N:14]=1)[CH2:3][CH2:4][CH2:5][CH2:6][CH3:7])(=[O:28])[CH3:27]

Participants

4

Reactant 2

HCID 50591-{3-[(Quinolin-2-yl)methoxy]phenyl}hexan-1-olHCID 7918Acetic Anhydride

Product 1

HCID 21280496HCID 21280496, compound

Reagents, catalysts & solvents 1

HCID 1049PyridineSolvent

Procedure

To a solution of 2-[[3-(1-hydroxyhexyl)phenoxymethyl]quinoline (1.7 g) in pyridine at 0° C. was added acetic anhydride (2.7 ml). The reaction mixture was stirred overnight at room temperature. The solvent was removed in vacuo to obtain the crude product.

Workup

  1. customThe solvent was removed in vacuo

Sources & evidence

ORD record
ord-50b4618c1f9f4b10b3d8c69a0b25365b
Source dataset
uspto-grants-1988_12
Patent number
US04794188

Reaction notes

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