Potassium Iodide → HCID 14349144, compound

Participants

Reaction Steps

This material was synthesized by refluxing a mixture of 2-chloromethyl quinoline (2.6 g, 14.5 mmol), 3-(5,5,5-trifluoropentanoyl)phenol (3.7 g, 15.9 mmol), powdered potassium carbonate (6.0 g, 43.5 mmol) and a catalytic amount of potassium iodide (0.1 g) in dry acetone (50 ml) for 14 hours. After this period, the mixture was filtered, and the filtrate was concentrated. The residue was dissolved in ether, and the ethereal solution was washed with brine, dried over MgSO4, and then concentrated in vacuo. The pure desired ketone was isolated by chromatography on silica gel using 20% ethyl acetate in hexanes as eluent. The product was obtained in 62% yield (3.4 g), had a melting point 80°-82° C. and was a yellowish solid.

Provenance & Evidence