HuagongsheHuagongshe Chemistry Print Report · For research reference only
methyl N-[3-(6,7-dimethoxy-2-methylaminoquinazolin-4-yl)phenyl]terephthalamic acid → methyl N-[3-(6,7-dimethoxy-2-methylaminoquinazolin-4-yl)phenyl]terephthalamic acid hydrate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | methyl N-[3-(6,7-dimethoxy-2-methylaminoquinazolin-4-yl)phenyl]terephthalamic acid | HCID 66646296 | — |
| Solvent | Acetone | HCID 180 | — |
| Product | methyl N-[3-(6,7-dimethoxy-2-methylaminoquinazolin-4-yl)phenyl]terephthalamic acid hydrate | HCID 68821413 | — |
Reaction Steps
The first crystals of methyl N-[3-(6,7-dimethoxy-2-methylaminoquinazolin-4-yl)phenyl]terephthalamic acid hydrate can be produced by dissolving methyl N-[3-(6,7-dimethoxy-2-methylaminoquinazolin-4-yl)phenyl]terephthalamic acid in acetone and precipitating crystals from the solution. More particularly, the first crystals of methyl N-[3-(6,7-dimethoxy-2-methylaminoquinazolin-4-yl)phenyl]terephthalamic acid hydrate can be produced by dissolving methyl N-[3-(6,7-dimethoxy-2-methylaminoquinazolin-4-yl)phenyl]terephthalamic acid in acetone at room temperature or under heating and slowly cooling the solution to 4° C. to room temperature to precipitate crystals from the solution.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08530654B2 |
| Source dataset | uspto-grants-2013_09 |
| ORD ID | ord-2509529920b945089a9ac75dbef9d957 |
| Source note | uspto-grants-2013_09 |